The Stem cells are the undifferentiated progenitor cells, are so called adult stem cells that have features of rebirth and healing against various damages of tissue. Stem Cells, having multi-potency, have a capability to differentiate to various mesoderm cells such as bone, cartilage, tendon, fat, heart, or muscle in the condition of in vivo as in vitro. Thus, stem cells are treated as the appropriate model for the research of the differentiation mechanism toward each tissue cell and are applied to the various cell-therapies. Main effect: winkle prevention, whitening etc.